COURSE INTRODUCTION AND APPLICATION INFORMATION

Course Name
Scientific Basis of Medicine V
Code
Semester
Theory
(hour/week)
Application/Lab
(hour/week)
Local Credits
ECTS
SBM 301
Fall
14
6
17
18
Prerequisites
None
Course Language
English
Course Type
Required
Course Level
First Cycle
Mode of Delivery -
Teaching Methods and Techniques of the Course
Course Coordinator
Course Lecturer(s)
Assistant(s)
Course Objectives The aim of this course is to learn the pathogenesis of diseases that occur due to deteriorated homeostasis. This course covers hematology, respiratory, circulatory, urinary, endocrine system diseases and metabolic disorders; focusing on the pathophysiology of common diseases, symptoms and signs, diagnostic algorithms, drugs used in treatment, prevention, and emergency treatment strategies.
Learning Outcomes The students who succeeded in this course;
  • 1. will be able to explain the pathophysiological mechanisms of genetic diseases and the principles of genetic counseling.
  • 2. will be able to explain the pathogenesis of hematological system diseases, associate their symptoms and signs with the pathophysiological mechanisms, explain the reasons of commonly used diagnostic methods, generate evidence-based diagnostic algorithms for selected clinical conditions, explain treatment principles and options, and describe the mechanisms of action, use, and adverse effects of drugs used to treat diseases.
  • 3. will be able to explain the pathogenesis of respiratory system diseases, associate their symptoms and signs with the pathophysiological mechanisms, explain the reasons of commonly used diagnostic methods, generate evidence-based diagnostic algorithms for selected clinical conditions, explain treatment principles and options, and describe the mechanisms of action use, and adverse effects of drugs used to treat diseases.
  • 4. will be able to explain the pathogenesis of cardiovascular system diseases, associate their symptoms and signs with the pathophysiological mechanisms, explain the reasons of commonly used diagnostic methods, generate evidence-based diagnostic algorithms for selected clinical conditions, explain treatment principles and options, and describe the mechanisms of action use, and adverse effects of drugs used to treat diseases.
  • 5. will be able to explain the pathogenesis of urinary system diseases, associate their symptoms and signs with the pathophysiological mechanisms, explain the reasons of commonly used diagnostic methods, generate evidence-based diagnostic algorithms for selected clinical conditions, explain treatment principles and options, and describe the mechanisms of action use, and adverse effects of drugs used to treat diseases.
  • 6. will be able to explain the pathogenesis of endocrine system diseases and metabolic disorders, associate their symptoms and signs with the pathophysiological mechanisms, explain the reasons of commonly used diagnostic methods, generate evidence-based diagnostic algorithms for selected clinical conditions, explain treatment principles and options, and describe the mechanisms of action use, and adverse effects of drugs used to treat diseases.
  • 7. will be able to discuss the sensitivity, specificity, and predictive values of diagnostic methods, and select the appropriate methods for routine and emergency situations.
  • 8. will be able to explain the pathophysiology of homeostatic disorders.
  • 9. associate diseases with lifestyle behavior and propose options for prevention.
  • 10. will be able to collect data to learn epidemiological characteristics of diseases which are the most common and/or the most common cause of death in Turkey and interpret them.
Course Description In this course, pathophysiology, diagnostic algorithms and treatment options of blood, respiratory, circulatory, urinary, endocrine system and metabolic disorders will be discussed.
Related Sustainable Development Goals

 



Course Category

 Core Courses
Major Area Courses
X
Supportive Courses
Media and Managment Skills Courses
Transferable Skill Courses

 

WEEKLY SUBJECTS AND RELATED PREPARATION STUDIES

Week Subjects Required Materials
1 Introduction to the clinical genetics Introduction to the hematological disorders 1. Hammer GD, McPhee SJ. Pathophysiology of Disease: An introduction to Clinical Medicine, 7th Edition, McGraw Hill Education, 2019.Chapter 2. 3-30 2. Hammer GD, McPhee SJ. Pathophysiology of Disease: An introduction to Clinical Medicine, 7th Edition, McGraw Hill Education, 2019.Chapter 6. 115-134 3. Nussbaum R. L., McInnes, R. R. & Willard H. F. The Chromosomal and Genomic Basis of Disease: Disorders of the Autosomes and Sex Chromosomes. Thompson and Thompson Genetics in Medicine 8th ed., Philadelphia, PA: Elsevier 2016. ISBN 978-1-4377-0696-3(pp. 54-63, 75-79, 94-97, 107-145, 189-216, 246-251, 283-287, 333-337, 369-381)
2 Hematological disorders 1. Hammer GD, McPhee SJ. Pathophysiology of Disease: An introduction to Clinical Medicine, 7th Edition, McGraw Hill Education, 2019.Chapter 5. 105-112 2. Katzung BG. Basic and Clinical Pharmacology, 14th Ed, McGraw-Hill Medical, 2018. Chapter 33 3. Robbins and Cotran Pathologic Basis of Disease, 9thEd, Elsevier Saunders, 2015. Chapter 13. 588-611.
3 Hematological disorders 1. Hammer GD, McPhee SJ. Pathophysiology of Disease: An introduction to Clinical Medicine, 7th Edition, McGraw Hill Education, 2019.Chapter 6. 135-144 2. Robbins and Cotran Pathologic Basis of Disease, 9thEd, Elsevier Saunders, 2015. Chapter 13. 588-611. 3. Nessar Ahmed, Clinical Biochemistry,Second Edition, Oxford University Press,2017; pp.493-494 4. Nussbaum R. L., McInnes, R. R. & Willard H. F. The Chromosomal and Genomic Basis of Disease: Disorders of the Autosomes and Sex Chromosomes. Thompson and Thompson Genetics in Medicine 8th ed., Philadelphia, PA: Elsevier 2016. ISBN 978-1-4377-0696-3(pp. 53-54, 432-433)
4 Hematological disorders 1. Aster JC, Bun HF. Pathophysiology of Blood Disorder, 2nd Edition, McGraw Hill Education, 2017. Chapter 25 Blood Transfusion. 2. Katzung BG. Basic and Clinical Pharmacology, 14th Ed, McGraw-Hill Medical, 2018. Chapter 34 3. Robbins and Cotran Pathologic Basis of Disease, 9thEd, Elsevier Saunders, 2015. Chapter 13. 588-611.
5 Respiratory system disorders 1. Hammer GD, McPhee SJ. Pathophysiology of Disease: An introduction to Clinical Medicine, 7th Edition, McGraw Hill Education, 2019. Chapter 4. 76-82 2. Hammer GD, McPhee SJ. Pathophysiology of Disease: An introduction to Clinical Medicine, 7th Edition, McGraw Hill Education, 2019. Chapter 9. 213-228
6 Respiratory system disorders 1. Hammer GD, McPhee SJ. Pathophysiology of Disease: An introduction to Clinical Medicine, 7th Edition, McGraw Hill Education, 2019. Chapter 9. 228-235 2. Robbins and Cotran Pathologic Basis of Disease, 9thEd, Elsevier Saunders, 2015. Chapter 15. 674-697.
7 Respiratory system disorders 1. Hammer GD, McPhee SJ. Pathophysiology of Disease: An introduction to Clinical Medicine, 7th Edition, McGraw Hill Education, 2019. Chapter 9. 235-253 2. Katzung BG. Basic and Clinical Pharmacology, 14th Ed, McGraw-Hill Medical, 2018. Chapter 6-10 3. Robbins and Cotran Pathologic Basis of Disease, 9thEd, Elsevier Saunders, 2015.Chapter 15. 712-722.
8 Circulatory system disorders 1. Hammer GD, McPhee SJ. Pathophysiology of Disease: An introduction to Clinical Medicine, 7th Edition, McGraw Hill Education, 2019. Chapter 10. 255-263 5
9 Circulatory system disorders 1. Hammer GD, McPhee SJ. Pathophysiology of Disease: An introduction to Clinical Medicine, 7th Edition, McGraw Hill Education, 2019. Chapter 10. 264-283 2. Hammer GD, McPhee SJ. Pathophysiology of Disease: An introduction to Clinical Medicine, 7th Edition, McGraw Hill Education, 2019. Chapter 4. 69-72 3. Katzung BG. Basic and Clinical Pharmacology, 14th Ed, McGraw-Hill Medical, 2018. Chapter 13-14 4. Robbins and Cotran Pathologic Basis of Disease, 9thEd, Elsevier Saunders, 2015. Chapter 12. 554-564. 5. Nessar Ahmed, Clinical Biochemistry,Second Edition, Oxford University Press,2017; pp.204-214
10 Circulatory system disorders 1. Hammer GD, McPhee SJ. Pathophysiology of Disease: An introduction to Clinical Medicine, 7th Edition, McGraw Hill Education, 2019. Chapter 10. 283-293 2. Hammer GD, McPhee SJ. Pathophysiology of Disease: An introduction to Clinical Medicine, 7th Edition, McGraw Hill Education, 2019. Chapter 11. 295-318 3. Katzung BG. Basic and Clinical Pharmacology, 14th Ed, McGraw-Hill Medical, 2018. Chapter 11-12-35 4. Robbins and Cotran Pathologic Basis of Disease, 9thEd, Elsevier Saunders, 2015. Chapter 11. 491-501. 5. Nessar Ahmed, Clinical Biochemistry,Second Edition, Oxford University Press,2017;pp.161-171.
11 Circulatory system disorders 1. Robbins and Cotran Pathologic Basis of Disease, 9thEd, Elsevier Saunders, 2015. Chapter 11. 491-501. 5
12 Urinary system disorders 1. Hammer GD, McPhee SJ. Pathophysiology of Disease: An introduction to Clinical Medicine, 7th Edition, McGraw Hill Education, 2019. Chapter 16. 455-481 2. Robbins and Cotran Pathologic Basis of Disease, 9thEd, Elsevier Saunders, 2015. Chapter 20. 899-927.
13 Urinary system disorders - Jawetz Melnick & Adelberg’s Medical Microbiology 27/E. Geo. Brooks, 2016 - Rubin’s Pathology.7th Ed. Wolters Kluwer,2015 - Robbins and Cotran Pathologic Basis of Disease, 9thEd, Elsevier Saunders, 2015 - Bertram G. Katzung, Anthony J. Trevor, Basic and Clinical Pharmacology, 13th Ed, McGraw-Hill Medical, 2015 - R S Greenberg. Medical Epidemiology 5th ed, 2015
14 Urinary system disorders 1. Robbins and Cotran Pathologic Basis of Disease, 9thEd, Elsevier Saunders, 2015. Chapter 20. 927-938,952-955.
15 Endocrine disorders 1. Hammer GD, McPhee SJ. Pathophysiology of Disease: An introduction to Clinical Medicine, 7th Edition, McGraw Hill Education, 2019. Chapter 18. 517-544 2. Katzung BG. Basic and Clinical Pharmacology, 14th Ed, McGraw-Hill Medical, 2018. Chapter 41 3. Classification and Diagnosis of Diabetes; ADA (American Diabetes Association; Diabetes Care 2016; 39 (Suppl) S13-22.
16 Endocrine disorders 1. Hammer GD, McPhee SJ. Pathophysiology of Disease: An introduction to Clinical Medicine, 7th Edition, McGraw Hill Education, 2019. Chapter 20. 571-589 2. Hammer GD, McPhee SJ. Pathophysiology of Disease: An introduction to Clinical Medicine, 7th Edition, McGraw Hill Education, 2019. Chapter 17. 483-513 3. Katzung BG. Basic and Clinical Pharmacology, 14th Ed, McGraw-Hill Medical, 2018. Chapter 38-42 4. Robbins and Cotran Pathologic Basis of Disease, 9thEd, Elsevier Saunders, 2015. Chapter 24. 1082-1105. 5. Nessar Ahmed, Clinical Biochemistry,Second Edition, Oxford University Press,2017;pp.284-298,254-266.
17 Endocrine disorders 1. Hammer GD, McPhee SJ. Pathophysiology of Disease: An introduction to Clinical Medicine, 7th Edition, McGraw Hill Education, 2019. Chapter 21. 593-623 2. Hammer GD, McPhee SJ. Pathophysiology of Disease: An introduction to Clinical Medicine, 7th Edition, McGraw Hill Education, 2019. Chapter 19. 545-569 3. Katzung BG. Basic and Clinical Pharmacology, 14th Ed, McGraw-Hill Medical, 2018. Chapter 37-39 4. Robbins and Cotran Pathologic Basis of Disease, 9thEd, Elsevier Saunders, 2015. Chapter 24. 1082-1105,1122-1135. 5. Nessar Ahmed, Clinical Biochemistry,Second Edition, Oxford University Press,2017;pp.345-365,112-114. 6. Guerrero RB, Salazar D & Tanpaiboon P. Laboratory Diagnoistci approaches in metabolic disorders. An Transl Med. 2018; Dec: Vol 6 (24)
18 Metabolic disorders 1. Robbins and Cotran Pathologic Basis of Disease, 9thEd, Elsevier Saunders, 2015. 2. Harper’s Illustrated Biochemistry, 30th Ed, Lange. Rodwell VW, Bender DA, Botham RM, Kennelly PJ, Weil PA. 2015 Chap 18-21,43, p 170-197, 517-525 3. Bertram G. Katzung, Anthony J. Trevor, Basic and Clinical Pharmacology, 13th Ed, McGraw-Hill Medical, 2015
Course Notes/Textbooks
  1. Hammer GD, McPhee SJ. Pathophysiology of Disease: An introduction to Clinical Medicine, 7th Edition, McGraw Hill Education, 2019.
  2. Stern SDC, Cifu AS, Atcorn D. Symptom to diagnosis: An Evidence-Based Guide, 3rd Edition, McGraw Hill Education, 2015.
  3. Aster JC, Bun HF. Pathophysiology of Blood Disorder, 2nd Edition, McGraw Hill Education, 2017.
  4. Katzung BG. Basic and Clinical Pharmacology, 14th Ed, McGraw-Hill Medical, 2018.
  5. Robbins and Cotran Pathologic Basis of Disease, 9thEd, Elsevier Saunders, 2015.
  6. Atlas of Microscopic Examination of Urine Sediment 2006. https://www.klimud.org/public/atlas/idrar/index.htm
  7. Nessar Ahmed, Clinical Biochemistry,Second Edition, Oxford University Press,2017
  8. Guerrero RB, Salazar D & Tanpaiboon P. Laboratory Diagnoistci approaches in metabolic disorders. An Transl Med. 2018; Dec: Vol  6 (24)
  9. Nussbaum R. L., McInnes, R. R. & Willard H. F. The Chromosomal and Genomic Basis of Disease: Disorders of the Autosomes and Sex Chromosomes. Thompson and Thompson Genetics in Medicine 8th ed., Philadelphia, PA: Elsevier 2016.  ISBN 978-1-4377-0696-3
Suggested Readings/Materials
  1. Raphael Rubin, David S. Strayer. Rubin's Pathology: Clinicopathologic Foundations of Medicine, 7th Ed. Wolters Kluwer,2015
  2. Classification and Diagnosis of Diabetes; ADA (American Diabetes Association; Diabetes Care 2016; 39 (Suppl) S13-22
  3. Harper’s Illustrated Biochemistry, 30th Ed, Lange. Rodwell VW, Bender DA, Botham RM, Kennelly PJ, Weil PA. 2015

 

EVALUATION SYSTEM

Semester Activities Number Weigthing
Participation
Laboratory / Application
Field Work
Quizzes / Studio Critiques
5
10
Portfolio
Homework / Assignments
1
10
Presentation / Jury
Project
Seminar / Workshop
Oral Exam
1
10
Midterm
5
50
Final Exam
1
20
Total

Weighting of Semester Activities on the Final Grade
12
80
Weighting of End-of-Semester Activities on the Final Grade
1
20
Total

ECTS / WORKLOAD TABLE

Semester Activities Number Duration (Hours) Workload
Course Hours
(Including exam week: 18 x total hours)
18
18
324
Laboratory / Application Hours
(Including exam week: 18 x total hours)
18
2
Study Hours Out of Class
18
3
54
Field Work
Quizzes / Studio Critiques
5
2
Portfolio
Homework / Assignments
1
10
Presentation / Jury
Project
Seminar / Workshop
Oral Exam
1
12
Midterms
5
10
Final Exams
1
14
    Total
510

 

COURSE LEARNING OUTCOMES AND PROGRAM QUALIFICATIONS RELATIONSHIP

#
 Program Competencies/Outcomes
* Contribution Level
1
2
3
4
5
1

Explain the normal structure and functions of the human body at the molecular, cellular, tissue, organ and system levels, associate them with suggestions, practices and clinical situations (nutrition, exercise, vaccination, mental health, etc.); to protect and improve the health of individuals.

 X
2

Describe the mechanisms of diseases at the molecular, cellular, tissue, organ and system levels and make evidence-based decisions by associating them with disease findings, diagnosis and treatment approaches.

 X
3

Consider the ethical principles, scientific facts, legal regulations and the biopsychosocial and cultural characteristics of the patient in the medical decision making process. Place importance and respect the autonomy of patients and the confidentiality of patient information, within the framework of the law and the provisions of healthcare application standards.

 X
4

Prioritize patient safety to minimize malpractice by carrying out risk assessment, take the necessary precautions, perform the necessary medical practice and record them.

 X
5

Communicate healthily, openly and effectively with healthcare workers, patients and their relatives, with the communication structured on empathy and care, trust and constructiveness; while being respectful to language, belief, race and cultural characteristics.

 X
6

By bearing in mind the patients’ values, beliefs, priorities, and needs; provide evidence-based options and include them in the decision making process.

 X
7

Preserve our planet’s resources and consider its effects on the public and individual’s health, advocate to disseminate healthy lifestyle behaviors and modify factors that affect health adversely.

 X
8

Reach current, valid and reliable information effectively using technology. Critically evaluate this information for solving problems in an evidence-based medical decision-making process, bearing in mind prevention, diagnosis, and management of diseases.

 X
9

Identify problems, create hypotheses, conduct research and employ teamwork to analyze results for generation and dissemination of health-related scientific knowledge.
10

By taking feedback and evaluating their performance, determine the areas and options for improvement and implement them within a plan.
11

Care for their own personal health, safety and appearance, take the necessary precautions in order to set an example for their colleagues and society.
12

Continuously renew themselves in their medical knowledge by always bearing in mind their commitment to lifelong learning principles.

 X
13

Using various communication tools, share their professionally gained knowledge in the field of healthcare, opinions, experiences, and evaluations with institutions, colleagues and the public.  Advocate for healthcare and contribute to developing policies to protect and improve it.

 X

*1 Lowest, 2 Low, 3 Average, 4 High, 5 Highest